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I graduated from Osaka City University Medical School, Japan in 1990 and then trained

as an Orthopedic Surgeon for 2 years. Following that, I decided to spend 4 years studying

malaria in Osaka City University’s Graduate School of Medicine. After I received my PhD,

I worked in the Laboratory of Parasitic Diseases (Louis H. Miller Lab), NIAID, NIH, USA

from 1997 to 1999.

 

In 2000, I became a faculty member in the Department of Molecular Parasitology (Prof. Motomi Torii Lab), Ehime University School of Medicine, Japan and joined the Institute of Tropical Medicine, Nagasaki University as a full time professor in 2007. I was inspired to study malaria by the Prof. Kazuyuki Tanabe’s lecture in 1986.

 

For more details, please read my memoir of Kazuyuki Tanabe published in Paraisotl Int (2014).

Prof. Osamu KANEKO

​

        095-819-7838

金子  修  教授

Professor Osamu KANEKO

​担当科目

経歴

  • Medical Microbiology II

  • Tropical Medicine II

MD, PhD

所属

Department of Protozoology, Institute of Tropical Medicine (NEKKEN),

Nagasaki University

研究領域

Malaria is a huge burden and responsible for many deaths in large areas of the tropical and sub-tropical world. In order to design and implement effective disease intervention strategies, I believe that one of the key priorities in malaria research should be the strengthening of our understanding of the basic biology of the parasite.

 

My team is currently investigating some fundamental aspects of the parasite’s life cycle, such as the mechanisms behind red blood cell (RBC) invasion and the phenomenon of cytoadherence of parasite-infected RBCs using human malaria parasite Plasmodium falciparum, monkey malaria parasite P. knowlesi and rodent malaria parasite P. yoelii.

 

I am also engaged in the field studies conducted in Thailand to understand the P. vivax biology in collaboration with Dr. Jetsumon Sattabongkot (Mahidol Vivax Research Center, Faculty of Tropical Medicine, Mahidol University, Thailand) and molecular epidemiology of P. falciparum in Kenya in collaboration with Prof. Akira Kaneko (Department of Parasitology, Osaka City University, Japan).

その他の関心分野

  • Evolution

専門分野

  • Molecular Biology

  • Malariology

  • Population Genetics

国/地域

  • Thailand

  • Kenya

メッセージ

　大学学部生時代に途上国に旅行し，感染症が世界的にいまだに大きな問題である事を感じていた時に，寄生虫学の講義で「マラリアは世界的規模で重大な疾患であるにもかかわらず，先進国はあまり関心を持たず，対策も遅れている」と聞いた。その言葉に，熱帯病をするならマラリアだ，と天啓を感じ，それ以来マラリアに取りつかれている。現在は，時々マラリア流行地に行きながらも，熱帯熱マラリア原虫やサルマラリア原虫，ネズミマラリア原虫の赤血球侵入や感染赤血球の改変現象を分子レベルで明らかにし，弱点を見出すべく，遺伝子改変技術を駆使した実験室内での解析を中心に研究をすすめている。

Select Publications

1

Plasmodium knowlesi Skeleton-Binding Protein 1 Localizes to the 'Sinton and Mulligan' Stipplings in the Cytoplasm of Monkey and Human Erythrocytes.

Lucky AB, Sakaguchi M, Katakai Y, Kawai S, Yahata K, Templeton TJ, Kaneko O. 

PLoS One 11(10):e0164272. (2016)

2

Ungulate malaria parasites.

Templeton TJ, Asada M, Jiratanh M, Ishikawa SA, Tiawsirisup S, Sivakumar T, Namangala B, Takeda M, Mohkaew K, Ngamjituea S, Inoue N, Sugimoto C, Inagaki Y, Suzuki Y, Yokoyama N, Kaewthamasorn M, Kaneko O. 

Sci Rep 6:23230. (2016)

3

Ca2+ monitoring in Plasmodium falciparum using the yellow cameleon-Nano biosensor.

Pandey K, Ferreira PE, Ishikawa T, Nagai T, Kaneko O, Yahata K. 

Sci Rep 6:23454. (2016)

4

Isolation of invasive Plasmodium yoelii merozoites with a long half-life to evaluate invasion dynamics and potential invasion inhibitors.

Mutungi JK, Yahata K, Sakaguchi M, Kaneko O.

Mol Biochem Parasitol 204(1):26-33. (2015)

5

The N-terminal segment of Plasmodium falciparum SURFIN4.1 is required for its trafficking to the red blood cell cytosol through the endoplasmic reticulum.

Zhu XT, Yahata K, Alexandre JSF, Tsuboi T, Kaneko O.

Parasito Int 62(2):215-29. (2013)

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