シャロン コックス 教授
Professor Sharon E. COX
BSc, MSc, PhD
担当科目
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Epidemiology I & II
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Statistics I & II
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Global Health Nutrition
経歴
I graduated from University College London with a BSc. (Biochemistry, First Class Hons)
in 1996, followed by a postgraduate teaching qualification (1997), a Masters in Public
Health Nutrition at the London School of Hygiene & Tropical Medicine [LSHTM] (1998)
and finally a PhD, also at LSHTM (2003). My PhD comprised a clinical trial of low-dose
maternal vitamin A supplementation to determine effects on immunity to malaria in
pregnancy in Ghana. In 2002 I became a staff member at LSHTM within the MRC
International Nutrition Group and worked on malaria and anemia in Gambian children. In
2007 I moved to be based in Dar es Salaam Tanzania, working mostly on sickle cell disease. In 2015 I was appointed as a Professor at School of Tropical Medicine & Global Health, Nagasaki University, where I am now based. I also hold a joint appointment at LSHTM.
所属
研究領域
I am interested in how nutrition underpins human health and in particular in relation to interactions with infections, other conditions like sickle cell disease and maternal and child health. My research aims to provide an evidence base to support nutrition-based interventions to improve health outcomes in populations in low and middle income countries.
Current ongoing studies are summarised below:
Nutrition and TB
I am leading research on nutrition and diabetes in TB patients in the Philippines, with a hospital based inpatient cohort which started in July 2016 & a cross-sectional outpatient study starting in 2017. The outpatient study is being conducted in TB-DOTS centres in metro Manila and rural sites in Negros Occidental. I am collaborating with investigators from San Lazaro Hospital, Manila, the Nutrition Centre, Philippines and the National TB programme.
Malnutrition in children
In Nepal I am leading a research project assessing the prevalence of malnutrition in pediatric admissions at Siddhi Memorial Hospital, Bhaktapur and associated risk of developing or worsening of nutritional status and risk of re-admission during 6 months follow-up post discharge. In Cambodia, we are conducting a study nested within a birth cohort (Research Title: Follow up survey on factors the influence on chronic malnutrition among children until two-years-old in rural Cambodia." Dr. Azusa Iwamoto, NCGM, Prof Rathvy, Director of National Maternal and Child Health Center) investigating the determinants of wasting in young children, with a focus on infections and gut inflammation.
Maternal and child health, nutrition and malaria
I am also involved in ongoing research on malaria elimination strategies and impacts on maternal and child health in Western Kenya, with collaborators from Osaka City University & Karolinska Institute, (Prof Akira Kaneko). I am also interested in how nutritional factors may affect risk and severity of malaria, in particular iron and iron supplementation.
Nutrition as a modulator of sickle cell disease
I have been conducting research with the Muhimbili Sickle Cohort in Tanzania, My research has focused on nutritional and genetic modulation of sickle cell disease (SCD) and recently completed a clinical trial of a nutraceutical intervention in children with SCD with primary endpoints of growth and improved vascular function. The data are currently being analysed. My main collaborators in MWP are Dr Julie Makani, (Muhimbili University of Health & Allied Sciences & University of Oxford) & Professor Charles Newton (University of Oxford & KEMRI-Kilifi, Kenya).
Key words: Malnutrition, Malaria, Nutrition, TB, Maternal Health, Sickle Cell Disease
専門分野
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Epidemiology
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Nutrition
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Maternal and child health
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Infectious diseases
国/地域
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The Philippines
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Nepal
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Bangladesh
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Cambodia
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UK
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Japan
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Tanzania
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Kenya
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The Gambia
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India
国/地域
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Nutrition and hypertension/vascular function
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The role of infections/early nutrition on risk of developing chronic diseases such as hypertension
 Assistant Prof Laura White (Nagasaki), Mam Clang (Nutrition Centre Philippines) and Valladolid Barangay Health workers during planning site visit for MAL-TB2 study. |  Mother feeding child during admission at Siddhi Memorial Hospital, Nepal |
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 Siddhi Memorial Hospital Bhaktapur, Nepal |
メッセージ
I propose that nutrition is one of the most important modifiable environmental factors underlying health and disease. Along with infections such as malaria, nutrition has been one of the strongest selection pressures over our recent evolutionary history. This has significant implications in relation to the rapid changes in diet and lifestyle that are occurring globally. Under and over-nutrition are increasingly occurring within the same population groups and in both low and high-income countries.
Nutrition is essential to consider at individual and community/population levels in order to ensure that health interventions are optimally successful.
My research focuses on understanding the mechanisms by which nutritional factors affect health outcomes, with a focus on low- and middle-income country settings and encompassing infectious and non-infectious disease processes.
Selected Publications
Mwangi MN, Roth JM, Smit MR, Trijsburg L, Mwangi AM, Demir AY, Wielders JP, Mens PF, Verweij JJ, Cox SE, Prentice AM, Brouwer ID, Savelkoul HF, Andang’o PE, Verhoef H. JAMA. 2015 Sep 8;314(10):1009-20.
Hepcidin expression distinguishes types of anaemia in African children.
Pasricha S, Atkinson SH, Armitage AE, Khandwala S, Veenemans J, Cox SE, Eddowes LA, Hayes T, Doherty CP, Demir AY, Tijhaar E, Verhoef H, Prentice AM, Drakesmith A. Science Trans Med: 6; 235re3.
Peripheral vascular response to inspiratory gasp in pediatric sickle cell anemia.
L’Esperance VS*, Cox SE*, Simpson D*, Gill C, Makani J, Soka D, Mgaya J, Kirkham FJ, Clough GF. Exp Physiol; 98: 49-56 [*shared first authorship]
Cox SE, Makani J, Komba AN, Soka D, Newton CR, Kirkham FJ & Prentice AM. Brit J Haematol; 155: 522-4
Cox SE, Makani J, Fulford AJ, Komba AN, Soka D, Williams TN, Newton CR, Marsh K, Prentice AM. Haematologica; 96: 948-53.