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I graduated from University College London with a BSc. (Biochemistry, First Class Hons)

in 1996, followed by a postgraduate teaching qualification (1997), a Masters in Public

Health Nutrition at the London School of Hygiene & Tropical Medicine [LSHTM] (1998)

and finally a PhD, also at LSHTM (2003). My PhD comprised a clinical trial of low-dose

maternal vitamin A supplementation to determine effects on immunity to malaria in

pregnancy in Ghana. In 2002 I became a staff member at LSHTM within the MRC

International Nutrition Group and worked on malaria and anemia in Gambian children. In

2007 I moved to be based in Dar es Salaam Tanzania, working mostly on sickle cell disease. In 2015 I was appointed as a Professor at School of Tropical Medicine & Global Health, Nagasaki University, where I am now based. I also hold a joint appointment at LSHTM.

Prof. Sharon E. COX

       + 81 (0)95 - 819 - 8583

Professor Sharon E. COX

シャロン  コックス

TMGH Modules

Background

  • Epidemiology I & II

  • Statistics I & II

  • Global Health Nutrition

BSc, MSc, PhD

Affiliations

Research Areas

I am interested in how nutrition underpins human health and in particular in relation to interactions with infections, other conditions like sickle cell disease and maternal and child health. My research aims to provide an evidence base to support nutrition-based interventions to improve health outcomes in populations in low and middle income countries. 
Current ongoing studies are summarised below:

Nutrition and TB
I am leading research on nutrition and diabetes in TB patients in the Philippines, with a hospital based inpatient cohort which started in July 2016  & a cross-sectional outpatient study starting in 2017. The outpatient study is being conducted in TB-DOTS centres in metro Manila and rural sites in Negros Occidental. I am collaborating with investigators from San Lazaro Hospital, Manila, the Nutrition Centre, Philippines and the National TB programme. 

Malnutrition in children 
In Nepal I am leading a research project assessing the prevalence of malnutrition in pediatric admissions at Siddhi Memorial Hospital, Bhaktapur and associated risk of developing or worsening of nutritional status and risk of re-admission during 6 months follow-up post discharge. In Cambodia, we are conducting a study nested within a birth cohort (Research Title: Follow up survey on factors the influence on chronic malnutrition among children until two-years-old in rural Cambodia." Dr. Azusa Iwamoto, NCGM, Prof Rathvy, Director of National Maternal and Child Health Center) investigating the determinants of wasting in young children, with a focus on infections and gut inflammation. 

Maternal and child health, nutrition and malaria
I am also involved in ongoing research on malaria elimination strategies and impacts on maternal and child health in Western Kenya, with collaborators from Osaka City University & Karolinska Institute, (Prof Akira Kaneko). I am also interested in how nutritional factors may affect risk and severity of malaria, in particular iron and iron supplementation. 

Nutrition as a modulator of sickle cell disease 
I have been conducting research with the Muhimbili Sickle Cohort in Tanzania, My research has focused on nutritional and genetic modulation of sickle cell disease (SCD) and recently completed a clinical trial of a nutraceutical intervention in children with SCD with primary endpoints of growth and improved vascular function. The data are currently being analysed. My main collaborators in MWP are Dr Julie Makani, (Muhimbili University of Health & Allied Sciences & University of Oxford) & Professor Charles Newton (University of Oxford & KEMRI-Kilifi, Kenya).

Key words:  Malnutrition, Malaria, Nutrition, TB, Maternal Health, Sickle Cell Disease
 

Disciplines

  • Epidemiology

  • Nutrition

  • Maternal and child health

  • Infectious diseases

Countries/Regions

  • The Philippines

  • Nepal

  • Bangladesh

  • Cambodia

  • UK

  • Japan

  • Tanzania

  • Kenya

  • The Gambia

  • India

Other Areas of Interest

  • Nutrition and hypertension/vascular function

  • The role of infections/early nutrition on risk of developing chronic diseases such as hypertension

Assistant Prof Laura White (Nagasaki), Mam Clang (Nutrition Centre Philippines) and Valladolid Barangay Health workers during planning site visit for MAL-TB2 study.

Mother feeding child during admission at Siddhi Memorial Hospital, Nepal

Siddhi Memorial Hospital Bhaktapur, Nepal

Selected Publications

1

Effect of Daily Antenatal Iron Supplementation on plasmodium Infection in Kenyan women: A Randomized Clinical Trial.

Mwangi MN, Roth JM, Smit MR, Trijsburg L, Mwangi AM, Demir AY, Wielders JP, Mens PF, Verweij JJ, Cox SE, Prentice AM, Brouwer ID, Savelkoul HF, Andang’o PE, Verhoef H. JAMA. 2015 Sep 8;314(10):1009-20.

Hepcidin expression distinguishes types of anaemia in African children.

Pasricha S, Atkinson SH, Armitage AE, Khandwala S, Veenemans J, Cox SE, Eddowes LA, Hayes T, Doherty CP, Demir AY, Tijhaar E, Verhoef H, Prentice AM, Drakesmith A. Science Trans Med: 6; 235re3.

Peripheral vascular response to inspiratory gasp in pediatric sickle cell anemia.

L’Esperance VS*, Cox SE*, Simpson D*, Gill C, Makani J, Soka D, Mgaya J, Kirkham FJ, Clough GF. Exp Physiol; 98: 49-56 [*shared first authorship]

Global arginine bioavailability in Tanzanian sickle cell patients at steady state: A nested case control study of deaths vs survivors.

Cox SE, Makani J, Komba AN, Soka D, Newton CR, Kirkham FJ & Prentice AM.  Brit J Haematol; 155: 522-4

Nutritional status, hospitalization and mortality among patients with sickle cell anemia in Tanzania.

Cox SE, Makani J, Fulford AJ, Komba AN, Soka D, Williams TN, Newton CR, Marsh K, Prentice AM. Haematologica; 96: 948-53.

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